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Increased BBB permeability leads to the accumulation of neurotoxic substances in the brain, which contribute to neuronal damage and loss [189]

J Biol Chem 279: 2593525938 Acknowledgements We thank The Wellcome Trust and the Biotechnology and Biological Sciences Research Council for financial support

wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

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Interestingly, you dont always start at the lowest dose of the new medication